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VASCULARIZATION
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
The organic process whereby body tissue becomes vascular and develops capillaries
Synonyms:
vascularisation; vascularization
Classified under:
Nouns denoting natural processes
Hypernyms ("vascularization" is a kind of...):
biological process; organic process (a process occurring in living organisms)
Derivation:
vascularize (make vascular)
vascularize (become vascular and have vessels that circulate fluids)
Context examples:
EGFR, HER2 and HER4 are RTKs that belong to the EGFR superfamily; they play major roles in both tumor cell proliferation and tumor vascularization and are overexpressed in many cancer cell types.
(Afatinib, NCI Thesaurus)
The regenerating limbs of the bioreactor-treated frogs were thicker with more developed bones, innervation, and vascularization.
(Scientists Help Frogs to Regenerate Their Limbs with Bioreactor Device, The Titi Tudorancea Bulletin)
Superficial vascularization of the cornea with infiltration of granulation tissue; an inflammatory exudate overlying the lining layer of synovial cells on the inside of a joint.
(Pannus Formation, NCI Thesaurus)
XL647 binds to and inhibits several tyrosine receptor kinases that play major roles in tumor cell proliferation and tumor vascularization, including epidermal growth factor receptor (EGFR; ERBB1), epidermal growth factor receptor 2 (HER2; ERBB2), vascular endothelial growth factor receptor (VEGFR), and ephrin B4 (EphB4).
(Multitargeted Tyrosine Kinase Inhibitor XL647, NCI Thesaurus)
Moving ahead, the team hopes to study the material in animal models to examine potential uses in tissue engineering and wound healing and to develop a better understanding of why the material promotes vascularization.
(Biomaterial Artificial Protein Helps Heal Tissue, The Titi Tudorancea Bulletin)
Anti-DLL4 monoclonal antibody REGN421 specifically binds to human DLL4, preventing its binding to Notch receptors and inhibiting Notch signaling, which may result in defective tumor vascularization and, so, the inhibition of tumor cell growth.
(Anti-Dll4 Monoclonal Antibody REGN421, NCI Thesaurus)
