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Vinculin
Definition 1
Encoded by a single human tumor suppressor VCL Gene, Vinculin contains 1,066 amino acids with strong similarity to other vinculins and alpha-catenins. Alternative splice product metavinculin contains additional 68-79 variable and highly conserved amino acids near the C-terminus. Involved in cell adhesion, vinculin is associated with the cytoplasmic face of adherens-type junctions and involved in anchoring F-actin to the plasma membrane. Vinculin is phosphorylated on serines, threonines and tyrosines and is acylated by myristic acid and/or palmitic acid. Vinculin exhibits self-association properties and appears to be the major talin-binding protein in platelets; 150 kD metavinculin also interacts strongly with talin. (OMIM, Swiss-Prot, LocusLink, and NCI) (NCI Thesaurus)
Definition 2
A cytoskeletal protein associated with cell-cell and cell-matrix interactions. The amino acid sequence of human vinculin has been determined. The protein consists of 1066 amino acid residues and its gene has been assigned to chromosome 10. (NLM, Medical Subject Headings)
Definition 3
actin-binding structural protein which serves to link microfilaments to other organelles in a variety of cell types. (NIH CRISP Thesaurus)
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