X-Ray Repair Cross Complementing Protein 3

X-Ray Repair Cross Complementing Protein 3 (XRCC3), encoded by the XRCC3 gene, is a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. XRCC3 interacts directly with RAD51 and may cooperate with RAD51 during recombinational repair. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity and exposure to UV radiation is a major risk factor for the development of malignant melanoma. DNA damage caused by UV radiation is thought to play a major role in carcinogenesis. The association between polymorphisms in DNA repair genes and the development of malignant melanoma, a T allele at position 18067 in exon 7 of the XRCC3 gene is significantly associated with melanoma development. (from OMIM 600675, LocusLink 7517 and NCI) (NCI Thesaurus)

YOU MAY ALSO LIKE

X-Ray Repair Cross Complementing Protein 2

X-Ray Repair Cross Complementing Protein 2, encoded by the XRCC2 gene, is a member of the RecA/Rad51-related protein family that participates in…

X-Ray Repair Cross Complementing Protein 1

X-Ray Repair Cross Complementing Protein 1 (XRCC1), encoded by the XRCC1 gene, functions in the repair of single-strand DNA breaks and sister…

X-Ray Photoelectron Spectroscopy

A quantitative spectroscopic technique that both determines the identities and percent composition of elements in a material and measures the elemental chemical…

X-Ray Fluorescence Spectrometry

A spectrometric method that determines the type and concentration of elements or chemicals in a sample, based upon the principle that each…

X-Ray Filter Thickness Minimum

The minimum thickness of the X-ray absorbing material used in the filter.

X-Ray Filter Thickness Maximum

The maximum thickness of the X-ray absorbing material used in the filter.