2IT-BAD monoclonal antibody 170

Pronunciation

Definition 1

A substance being studied in the treatment of cancer. It is made by linking a monoclonal antibody called 170, which binds to a protein called MUC-1, to a substance called 2IT-BAD, which binds radioactive substances. 2IT-BAD monoclonal antibody 170 may be used to detect cancer cells and kill them. It is a type of immunoconjugate. (NCI Dictionary)

Definition 2

An immunoconjugate of a metal chelator, 2IT-BAD (2-iminothiolane-2-[p-(bromoacetamido)benzyl]-1,4,7,10-tetraazacyclododecane-N,N',N",N"'-tetraacetic acid ), and a panadenocarcinoma murine monoclonal antibody (MoAb) m170. MoAb m170 recognizes MUC-1 antigen present on the surface of many adenocarcinomas. 2IT-BAD MoAb m170 can readily chelate any radioisotope and be used in diagnostic procedures or in the treatment of MUC-1 expressing adenocarcinomas. (NCI Thesaurus)

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