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A Kinase Anchor Protein 12
Definition 1
Encoded by human AKAP12 Gene, A Kinase Anchor Protein 12 is expressed in endothelial cells, but not in platelets or peripheral blood cells. The 1,781-amino acid 191 kD cytoplasmic anchoring protein appears to mediate compartmentation of PKA and PKC in the cortical cytoskeleton. Its amphipathic alpha helix binds to the PKA RII subunit and tethers the enzyme near its substrates. Activated by lysopc, AKAP12 inhibits PKC. Polybasic regions are involved in binding PKC. (OMIM, Swiss-Prot, and NCI) (NCI Thesaurus)
Definition 2
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. (NCI Thesaurus/LocusLink)
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