| Library / English Dictionary |
ACTIVE SITE
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
The part of an enzyme or antibody where the chemical reaction occurs
Classified under:
Nouns denoting spatial position
Hypernyms ("active site" is a kind of...):
site; situation (physical position in relation to the surroundings)
Holonyms ("active site" is a part of...):
enzyme (any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions)
antibody (any of a large variety of proteins normally present in the body or produced in response to an antigen which it neutralizes, thus producing an immune response)
Context examples:
It’s possible that iron cyano-carbonyl complexes may have been a precursor to these active sites and later incorporated into proteins billions of years ago.
(Cyanide Compounds Discovered in Meteorites May Hold Clues to the Origin of Life, NASA)
An essential amino acid in juvenile humans, Arginine is a complex amino acid, often found at active site in proteins and enzymes due to its amine-containing side chain.
(Arginine, NCI Thesaurus)
Two thirds of the proteins with an ADAM type metalloprotease domain also contain the zinc protease pattern which locates the active site of these proteases.
(ADAM Type Metalloprotease Domain, NCI Thesaurus)
This alteration in amino acid sequence causes an alteration of the 3D protein structure in close vicinity to the active site that abolishes the enzymatic activity of the cytochrome P450 2D6*7 protein.
(CYP2D6*7 Allele, NCI Thesaurus)
These compounds do not bind to the active site of the polymerase but in a less conserved pocket near the active site, causing a distortion in the shape of the active site and resulting in inhibition of enzymatic function, chain termination, and inhibition of viral replication.
(Non-nucleoside Reverse Transcriptase Inhibitor, NCI Thesaurus)
Marizomib irreversibly binds to and inhibits the 20S catalytic core subunit of the proteasome by covalently modifying its active site threonine residues; inhibition of ubiquitin-proteasome mediated proteolysis results in an accumulation of poly-ubiquitinated proteins, which may result in the disruption of cellular processes, cell cycle arrest, the induction of apoptosis, and the inhibition of tumor growth and angiogenesis.
(Marizomib, NCI Thesaurus)
Complementary to the template region of telomerase RNA (hTR), imetelstat acts as a competitive enzyme inhibitor that binds and blocks the active site of the enzyme (a telomerase template antagonist), a mechanism of action which differs from that for the antisense oligonucleotide-mediated inhibition of telomerase activity through telomerase mRNA binding.
(Imetelstat Sodium, NCI Thesaurus)
Marimastat covalently binds to the zinc(II) ion in the active site of matrix metalloproteinases (MMPs), thereby inhibiting the action of MMPs, inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis.
(Marimastat, NCI Thesaurus)
This agent reversibly binds to the thrombin active site, thereby preventing the thrombin-dependent reactions, which include the conversion of fibrinogen to fibrin; the activation of factors V, VIII and XI; the activation of protein C; and platelet aggregation.
(Argatroban Anhydrous, NCI Thesaurus)
Batimastat binds covalently to the zinc ion in the active site of matrix metalloproteinases (MMPs), thereby inhibiting the action of MMPs, inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis.
(Batimastat, NCI Thesaurus)
