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ANTAGONISTIC
| Pronunciation (US): |  | (GB): | |
I. (adjective)
Sense 1
Meaning:
Incapable of harmonious association
Classified under:
Similar:
incompatible (not compatible)
Derivation:
antagonism (a state of deep-seated ill-will)
Sense 2
Meaning:
Used especially of drugs or muscles that counteract or neutralize each other's effect
Synonyms:
antagonistic; incompatible
Classified under:
Similar:
antacid (acting to neutralize acid (especially in the stomach))
antiphlogistic (counteracting inflammation)
Antonym:
synergistic (used especially of drugs or muscles that work together so the total effect is greater than the sum of the two (or more))
Derivation:
antagonism ((biochemistry) interference in or inhibition of the physiological action of a chemical substance by another having a similar structure)
antagonist (a drug that neutralizes or counteracts the effects of another drug)
antagonist (a muscle that relaxes while another contracts)
Sense 3
Meaning:
Arousing animosity or hostility
Example:
Europe was antagonistic to the Unites States
Classified under:
Adjectives
Similar:
alienating (causing hostility or loss of friendliness)
Antonym:
conciliatory (intended to placate)
Derivation:
antagonism (an actively expressed feeling of dislike and hostility)
Sense 4
Meaning:
Characterized by antagonism or antipathy
Example:
antipathetic factions within the party
Synonyms:
antagonistic; antipathetic; antipathetical
Classified under:
Adjectives
Similar:
hostile (characterized by enmity or ill will)
Derivation:
antagonism (the relation between opposing principles or forces or factors)
antagonism (a state of deep-seated ill-will)
Sense 5
Meaning:
Indicating opposition or resistance
Synonyms:
antagonistic; counter
Classified under:
Adjectives
Similar:
negative (characterized by or displaying negation or denial or opposition or resistance; having no positive features)
Derivation:
antagonism (the relation between opposing principles or forces or factors)
antagonist (someone who offers opposition)
Context examples:
In addition, these agents have peripherally or centrally antagonistic activity against alpha adrenergic, serotonergic, histaminic, and muscarinic receptors.
(Phenothiazine, NCI Thesaurus)
A transcription factor called DREAM (DRE antagonistic modulator) binds to the DRE and represses prodynorphin transcription when bound.
(Pain Repression Pathway, NCI Thesaurus/BIOCARTA)
In addition, orphenadrine exerts antagonistic effects on histamine H1 receptors.
(Orphenadrine, NCI Thesaurus)
A noroxymorphone derivative with competitive opioid antagonistic property.
(Naltrexone, NCI Thesaurus)
The hydrochloride salt of naltrexone, a noroxymorphone derivative with competitive opioid antagonistic activity.
(Naltrexone hydrochloride, NCI Thesaurus)
Favorably disposed; not antagonistic or hostile.
(Friendly, NCI Thesaurus)
In addition, the antagonistic effect on AT1 in the adrenal gland, prevents angiotensin II-induced stimulation of aldosterone synthesis and secretion by the adrenal cortex.
(Forasartan, NCI Thesaurus)
Aripiprazole has partial agonistic activity at dopamine D2 receptors and serotonin 5-HT1A receptors, as well as potent antagonistic activity on serotonin 5-HT2A receptors.
(Aripiprazole, NCI Thesaurus)
The hydrochloride salt form of bromodiphenhydramine, a synthetic ethanolamine with histamine H1 antagonistic and sedative properties.
(Bromodiphenhydramine Hydrochloride, NCI Thesaurus)
The phosphate salt of antazoline, an ethylenediamine derivative with histamine H1 antagonistic and sedative properties.
(Antazoline Phosphate, NCI Thesaurus)
