Library / English Dictionary

APOPTOSIS

Pronunciation (US):

(GB):

 I. (noun) 

Sense 1

Meaning:

A type of cell death in which the cell uses specialized cellular machinery to kill itself; a cell suicide mechanism that enables metazoans to control cell number and eliminate cells that threaten the animal's survival

Synonyms:

apoptosis; caspase-mediated cell death; programmed cell death

Classified under:

Nouns denoting natural phenomena

Hypernyms ("apoptosis" is a kind of...):

cell death; necrobiosis ((physiology) the normal degeneration and death of living cells (as in various epithelial cells))

Credits

 Context examples: 

MET tyrosine kinase inhibitor EMD 1214063 selectively binds to MET tyrosine kinase and disrupts MET signal transduction pathways, which may induce apoptosis in tumor cells overexpressing this kinase.

(MET Tyrosine Kinase Inhibitor EMD 1214063, NCI Thesaurus)

Upon oral administration, BCR-ABL tyrosine kinase inhibitor BL001 may inhibit the BCL-ABL protein, which may lead to decreased proliferation and enhanced apoptosis in tumor cells.

(Metatinib Tromethamine, NCI Thesaurus)

Although the exact mechanism through which this agent induces apoptosis is unknown, it may involve antibody-dependent cellular cytotoxicity (ADCC) or complement-mediated cytotoxicity (CMC).

(Milatuzumab, NCI Thesaurus)

This agent also inhibits the anti-apoptotic mitogen-activated protein kinase (MAPK) pathway and modulates the balance between the MAPK and pro-apoptotic stress-activated protein kinase (SAPK/JNK) pathways, thereby inducing apoptosis.

(Miltefosine, NCI Thesaurus)

This allele, which encodes lactadherin, is involved in apoptosis and integrin interactions.

(MFGE8 wt Allele, NCI Thesaurus)

Methoxyamine covalently binds to apurinic/apyrimidinic (AP) DNA damage sites and inhibits base excision repair (BER), which may result in an increase in DNA strand breaks and apoptosis.

(Methoxyamine, NCI Thesaurus)

Methoxyamine covalently binds to apurinic/apyrimidinic DNA damage sites and thereby inhibits base excision repair (BER) process, which may prevent repair of DNA strand breaks and result in an induction of apoptosis.

(Methoxyamine hydrochloride, NCI Thesaurus)

In addition, this agent has induced apoptosis in mouse thymocytes and inhibits the G2/M phase of the cell cycle.

(Methyl 2,5-dihydroxycinnamate, NCI Thesaurus)

This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis in sensitive tumor cell populations.

(Methylprednisolone, NCI Thesaurus)

This protein is involved in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation.

(Mitogen-Activated Protein Kinase Kinase Kinase 5, NCI Thesaurus)