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CELL DEATH
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I. (noun)
Sense 1
Meaning:
(physiology) the normal degeneration and death of living cells (as in various epithelial cells)
Synonyms:
cell death; necrobiosis
Classified under:
Nouns denoting natural phenomena
Hypernyms ("cell death" is a kind of...):
death (the permanent end of all life functions in an organism or part of an organism)
Domain category:
physiology (the branch of the biological sciences dealing with the functioning of organisms)
Hyponyms (each of the following is a kind of "cell death"):
apoptosis; caspase-mediated cell death; programmed cell death (a type of cell death in which the cell uses specialized cellular machinery to kill itself; a cell suicide mechanism that enables metazoans to control cell number and eliminate cells that threaten the animal's survival)
Context examples:
Any cellular process that decreases the frequency, rate or extent of cell death by apoptosis.
(Negative Regulation of Apoptosis, NCI Thesaurus)
A cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents.
(Necrotic Process, NCI Thesaurus)
In addition, this cancer-cell based vaccine may induce a cytotoxic T lymphocyte (CTL) response against prostate specific tumor associated antigens, resulting in an immune-mediated prostate cancer cell death.
(AdRTVP-1-Transduced Prostate Cancer Cell-Based Vaccine, NCI Thesaurus)
Programmed cell death is induced by many different factors and involves numerous signaling pathways, some dependent on caspase proteases and others that are caspase independent.
(AIF Pathway, NCI Thesaurus/BIOCARTA)
This leads to leakage of important intracellular components, cell rupture, and eventually cell death.
(amphotericin B, NCI Thesaurus)
Aminosalicylic acid exerts its bacteriostatic activity against Mycobacterium tuberculosis by competing with PABA for enzymes involved in folate synthesis, thereby suppressing growth and reproduction of M. tuberculosis, eventually leading to cell death.
(Aminosalicylic Acid, NCI Thesaurus)
In the cytoplasm, LF acts as a protease that cleaves MAP kinase kinase (MAPKK 1 and MAPKK 2), inhibiting pathways that rely on this kinase family and causing cell death.
(Anthrax Toxin Pathway, NCI Thesaurus/BIOCARTA)
Amrubicin intercalates into DNA and inhibits the activity of topoisomerase II, resulting in inhibition of DNA replication, and RNA and protein synthesis, followed by cell growth inhibition and cell death.
(Amrubicin, NCI Thesaurus)
Following binding, monoclonal antibody RAV12 disrupts sodium channels of tumor cells expressing this glycotope, resulting in cell and organelle swelling, loss of membrane integrity, and cell death.
(Monoclonal Antibody RAV12, NCI Thesaurus)
Although the exact mechanism remains to be elucidated, mefloquine, a weak base, preferentially accumulates in lysosomes and disrupts lysosomal function and integrity, thereby leading to host cell death.
(Mefloquine, NCI Thesaurus)
