Health / Medical Topics

    APS Protein

    Encoded by human APS Gene, 85 kD APS Protein appears to be found in spleen, prostate, testis, uterus, small intestine, skeletal muscle, and peripheral blood leukocytes. The 632-amino acid adaptor protein contains a PH domain, a SH2 domain, and a C-terminal tyrosine phosphorylation site. APS is structurally similar to the T-cell adaptor protein/signal transducer LNK and is tyrosine-phosphorylated after BCR cross-linking. APS associates with SHC regardless of BCR stimulation and with GRB2 after BCR stimulation. (OMIM and NCI) (NCI Thesaurus)




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