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ATTENUATE
| Pronunciation (US): |  | (GB): | |
I. (adjective)
Sense 1
Meaning:
Reduced in strength
Example:
the faded tones of an old recording
Synonyms:
attenuate; attenuated; faded; weakened
Classified under:
Similar:
decreased; reduced (made less in size or amount or degree)
II. (verb)
Verb forms
Present simple: I / you / we / they attenuate ... he / she / it attenuates
Past simple: attenuated
Past participle: attenuated
-ing form: attenuating
Sense 1
Meaning:
Become weaker, in strength, value, or magnitude
Classified under:
Verbs of size, temperature change, intensifying, etc.
Hypernyms (to "attenuate" is one way to...):
weaken (become weaker)
Troponyms (each of the following is one way to "attenuate"):
refine (attenuate or reduce in vigor, strength, or intensity by polishing or purifying)
Sentence frame:
Something ----s
Derivation:
attenuation (weakening in force or intensity)
attenuator (an electrical device for attenuating the strength of an electrical signal)
Sense 2
Meaning:
Weaken the consistency of (a chemical substance)
Synonyms:
attenuate; rarefy
Classified under:
Verbs of size, temperature change, intensifying, etc.
Hypernyms (to "attenuate" is one way to...):
weaken (lessen the strength of)
Domain category:
chemical science; chemistry (the science of matter; the branch of the natural sciences dealing with the composition of substances and their properties and reactions)
Sentence frames:
Somebody ----s something
Something ----s something
Derivation:
attenuation (the property of something that has been weakened or reduced in thickness or density)
Context examples:
An attenuated oncolytic Edmonston (Ed) strain of measles virus encoding the human thyroidal sodium iodide symporter (MV-NIS) with potential antineoplastic activity.
(Oncolytic Measles Virus Encoding Thyroidal Sodium Iodide Symporter, NCI Thesaurus)
An oncolytic viral agent containing the oncolytic, live-attenuated strain of the paramyxovirus Newcastle disease virus (NDV), with potential antineoplastic activity.
(Oncolytic Newcastle Disease Virus, NCI Thesaurus)
A vaccine that contains live attenuated polio virus.
(Oral Polio Vaccine, NCI Thesaurus)
A gene therapy agent containing an attenuated, replication-competent, genetically engineered mutant form of the Herpes simplex virus 1 (HSV-1) strain KOS with potential antineoplastic activity.
(Oncolytic HSV-1 rRp450, NCI Thesaurus)
In addition, rhEGF may attenuate epithelial cytotoxicities related to chemotherapy and/or radiotherapy.
(Nepidermin, NCI Thesaurus)
Originally developed for the eradication of smallpox, MVA is a highly attenuated and replication-defective strain incapable of virion assembly and exerts potent immunostimulatory activity against antigens.
(MVA-MUC1-IL2 Vaccine, NCI Thesaurus)
An attenuated form of Mycobacterium bovis that is used to generate the Bacillus Calmette-Guerin vaccine.
(Mycobacterium bovis BCG, NCI Thesaurus)
An attenuated strain of Mycobacterium w, a non-pathogenic, rapidly growing, atypical mycobacterium, with non-specific immunopotentiating properties.
(Mycobacterium w, NCI Thesaurus)
GRKs attenuate GPCR signaling in concert with arrestins, proteins that bind GRK-phosphorylated GPCRs to disrupt interaction with G-protein and to terminate signaling.
(Attenuation of GPCR Signaling Pathway, NCI Thesaurus/BIOCARTA)
A flattened cell of the alveolar epithelium, distinguished by their greatly attenuated cytoplasm and paucity of organelles.
(Alveolar Cell Type I, NCI Thesaurus)
