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Brain-Derived Neurotrophic Factor
Definition 1
Brain-Derived Neurotrophic Factor is a member of the nerve growth factor family. It exerts trophic action on retinal, cholinergic, and dopaminergic neurons in the brain and on motor and sensory neurons in the peripheral nervous system. Target cells regulate neuronal survival by producing neurotrophic factors, such as NGF and BDNF, which show sequence similarity. Proforms of NGF and BDNF are secreted and cleaved by plasmin serine protease and matrix metalloproteinases (MMP7, MMP3); proforms preferentially activate p75(NTR) to mediate apoptosis and mature forms activate TRK receptors to promote survival. Huntingtin up regulates transcription of BDNF. Mutated Huntingtin decreases production of BDNF leading to neuronal death. (from OMIM 113505 and NCI) (NCI Thesaurus)
Definition 2
A member of the nerve growth factor family of trophic factors. In the brain BDNF has a trophic action on retinal, cholinergic, and dopaminergic neurons, and in the peripheral nervous system it acts on both motor and sensory neurons. (From Kendrew, The Encyclopedia of Molecular Biology, 1994) (NLM, Medical Subject Headings)
Definition 3
member of the neurotrophin family of peptide growth factors. (NIH CRISP Thesaurus)
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