Matrix metalloproteinase

Pronunciation

Definition 1

A member of a group of enzymes that can break down proteins, such as collagen, that are normally found in the spaces between cells in tissues (i.e., extracellular matrix proteins). Because these enzymes need zinc or calcium atoms to work properly, they are called metalloproteinases. Matrix metalloproteinases are involved in wound healing, angiogenesis, and tumor cell metastasis. (NCI Dictionary)

Definition 2

Matrix metalloproteinases are Zn(2+)-binding endopeptidases that degrade components of the extracellular matrix. These enzymes are implicated in tissue remodeling processes, wound healing, angiogenesis, and tumor invasion. Matrix metalloproteinases have been associated with the development of advanced-stage cancer via their role in tumor progression, invasion, and metastasis. (NCI Thesaurus)

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