| Health / Medical Topics |
Matrix Gla Protein
Upregulated by vitamin D in bone cells and expressed at high levels in heart, kidney, and lung by human MGP Gene (Osteocalcin/MGP Family), 103-aa 12-kDa (precursor) secreted Matrix Gla Protein is associated with the organic matrix of bone and cartilage and is a putative inhibitor of bone formation. Like all known vertebrate vitamin K-dependent proteins, MGP contains a transmembrane signal peptide, a putative gamma-carboxylase recognition site, and a Gla-containing domain. MGP requires vitamin K-dependent gamma-carboxylation for its function. (NCI Thesaurus)
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