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Capromab pendetide
Pronunciation
Definition 1
A substance used to detect prostate cancer. It contains a monoclonal antibody that binds to prostate cells, linked to a substance that can bind radioisotopes. Capromab pendetide is combined with indium 111 and injected into the body. A gamma camera (a special camera that detects radioactivity) is used to find prostate cancer cells in the body. Capromab pendetide is a type of immunoconjugate. Also called ProstaScint. (NCI Dictionary)
Definition 2
An immunoconjugate of the murine monoclonal antibody, 7E11-C5.3 (Capromab), conjugated to the linker-chelator, glycyl-tyrosyl-(N,-diethylenetriaminepentaacetic acid)-lysine hydrochloride (GYK-DTPA-HCl). Capromab, an IgG1 kappa immunoglobulin, binds specifically to a cytoplasmic epitope of prostate-specific membrane glycoprotein (PSMA) that is only expressed by prostatic epithelial cells (benign and malignant). Capromab pendetide can be used in diagnosis or detection of prostate cancer when labeled with Indium I-111, which emits gamma radiation and X-Ray photons that can be captured by gamma camera allowing imaging of PMSA expressing tissues. (NCI Thesaurus)
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