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Caveolin 1
Definition 1
Caveolin 1 (CAV1), encoded by the CAV1 gene, is a scaffolding protein and the main component of the caveolae plasma membranes found in most cell types. CAV1 and CAV2 form Caveolin, a stable hetero-oligomeric complex important in the formation and maintenance of caveolae. In the absence of caveolin no morphologically identifiable caveolae exist, with one exception where in neuronal cells CAV 1 and CAV 2 are expressed but there are no morphologically recognizable caveolae. Caveolin 1 links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. Caveolin expression is correlated both to oncogenic transformation and its reversal. CAV1 is a tumor suppressor candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. Alternative splicing results in 2 isoform proteins (alpha, beta). (NCI Thesaurus)
Definition 2
Caveolin-1 is a 24 kD homooligomeric caveolar integral membrane protein that may organize signal transduction molecules as a scaffolding protein. Caveolins may allow tighter control and integration of multiple signal transduction pathways to reduce indiscriminate cross-talk. Caveolins interact with G proteins and link alpha integrin to FYN tyrosine kinase, SHC, GRB2 and the RAS-ERK pathway in promoting cell cycle progression. Caveolins are also implicated in drug resistance in cancer cells. (from OMIM 601047 and NCI) (NCI Thesaurus)
Definition 3
only known molecule associated with the striated coat that decorates the inside of caveolar membranes. (NIH CRISP Thesaurus)
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