CBL Protein

The cellular homologue of v-cbl, CBL protein is expressed in a range of hemopoietic lineages. Malignancies are associated with translocations of the CBL gene. Adaptor protein CBL2, containing a RING finger and multiple SH3 domains, encodes a protein similar to SLI1, a negative regulator of an EGF receptor tyrosine kinase homologue. Through its SH2 domain, CBL regulates activated tyrosine-phosphorylated receptor PTK ubiquitination as an E3 ubiquitin ligase and recruits, and activates, an E2 ubiquitin-conjugating enzyme through its RING domain. CBL is recruited to the tyrosine kinase insulin receptor by CAP adaptor protein, through a CAP SH3 domain. Upon CBL phosphorylation, CAP/CBL dissociates from the receptor to complex with caveolar flotillin and localize to plasma membrane lipid rafts. (from OMIM 165360 and NCI) (NCI Thesaurus)

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This gene is involved in hematopoiesis and osteogenesis.