CD4 Antigen

Definition 1

CD4 Antigen, encoded by the CD4 gene, is a T-cell surface glycoprotein. CD4 has a role in cell-cell interactions and may act in signal transduction. CD4 is a accessory protein for MHC class-II antigen/T-cell receptor interaction and functions to initiate or augment the early phase of T-cell activation. CD4 enhances T-cell sensitivity to antigen and binds to LCK, which phosphorylates CD3-zeta. CD4 Antigen also serves as an HIV receptor, binding directly to the envelope protein gp120 on HIV. (From LocusLink, OMIM and NCI) (NCI Thesaurus)

Definition 2

helper T-lymphocyte marker that functions as a receptor for MHC class II antigen; also acts as the receptor for HIV. (NIH CRISP Thesaurus)

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