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CD8
I. (noun)
Sense 1
Meaning:
A membrane glycoprotein that is found primarily on the surface of cytotoxic T cells
Synonyms:
CD8; cluster of differentiation 8
Classified under:
Hypernyms ("CD8" is a kind of...):
glycoprotein (a conjugated protein having a carbohydrate component)
Context examples:
It binds to CD4, CD8 and IL-2R beta chain cytoplasmic domains. p56LCK is quickly activated by mIg cross-linking on B-cells or by TCR cross-linking.
(Oncogene LCK, NCI Thesaurus)
Upon subcutaneous administration, pegylated recombinant human interleukin-10 AM0010 may activate cell-mediated immunity against cancer cells by stimulating the differentiation and expansion of tumor specific cytotoxic CD8+ T cells.
(Pegylated Recombinant Human Interleukin-10 AM0010, NCI Thesaurus)
Some CD8 cells recognize and kill cancerous cells and those infected by intracellular pathogens (some bacteria, viruses and mycoplasma) and they are called cytotoxic T-lymphocytes
(Murine CD8-Positive T-Lymphocytes, NCI Thesaurus)
This protein plays a role in activation of cytolysis by natural killer cells, CD8 alpha-beta T cells, and gamma-delta T cells.
(MHC Class I Polypeptide-Related Sequence B, NCI Thesaurus)
This allele, which encodes MHC class I polypeptide-related sequence B protein, is involved in cytolytic activation of natural killer cells, CD8 alpha-beta T cells, and gamma-delta T cells.
(MICB wt Allele, NCI Thesaurus)
The antigen LEU 2A, also known as CD8, is present on a subset of natural killer (NK) lymphocytes as well as the on the human suppressor/cytotoxic T-lymphocyte subset.
(Monoclonal Antibody hLEU 2A, NCI Thesaurus)
Any monoclonal antibody directed against the cell surface glycoprotein CD8, regardless of the antibody type.
(Anti-CD8 Monoclonal Antibody, NCI Thesaurus)
Live-attenuated vaccines are used when a CD8+ T Cell (cellular cytotoxicity) response is desired.
(Attenuated Live Virus Vaccine, NCI Thesaurus)
Depleting CD8+ T cells or neutralizing IL-17A removed this protective effect.
(Skin Microbes and the Immune Response, NIH)
Upon administration, allogeneic large multivalent immunogen melanoma vaccine LP2307 may stimulate a CD8+ cytotoxic T lymphocyte (CTL) response against melanoma tumor cells that express melanoma-specific LMI.
(Allogeneic Large Multivalent Immunogen Melanoma Vaccine LP2307, NCI Thesaurus)
