CDC7L1 Kinase Complex

The G1/S transition in eukaryotic cells is strictly regulated so that DNA replication occurs only once during S phase. The CDC7L1 kinase complex may trigger S phase by directly activating the replication initiation complexes assembled at the origins. Phosphorylation of MCM2 and MCM3 in the MCM complex by the CDC7L1 kinase complex converts the inactive MCM complex into an active helicase. Activator of S Phase Kinase, encoded by the ASK gene, is a cyclin-like regulatory subunit of the CDC7L1 kinase complex. This protein is the major activator of CDC7L1. ASK plays a pivotal role in the G1/S transition in mammalian cells and its function is essential for entry into S phase. ASK interacts with CDC7L1 and stimulates the kinase activity of CDC7L1. CDC7L1-dependent kinase activity reflects the ASK protein level, significantly increasing in cells in S phase, and ASK protein is extensively phosphorylated during S phase, presumably by CDC7L1. (NCI Thesaurus)

YOU MAY ALSO LIKE

CDC73 wt Allele

Human CDC73 wild-type allele is located in the vicinity of 1q25 and is approximately 132 kb in length. This allele, which encodes…

CDC73 Gene

This gene is involved in transcription and may play a role in cell cycle progression.

CDC7 wt Allele

Human CDC7 wild-type allele is located in the vicinity of 1p22 and is approximately 25 kb in length. This allele, which encodes…

CDC7 Kinase Inhibitor NMS-1116354

An orally bioavailable cell division cycle 7 homolog (CDC7) kinase inhibitor with potential antineoplastic activity. CDC7 kinase inhibitor NMS-1116354 binds to and…

CDC7 Kinase Inhibitor BMS-863233

An orally bioavailable cell division cycle 7 homolog (CDC7) kinase inhibitor with potential antineoplastic activity. CDC7 kinase inhibitor BMS-863233 binds to and…

CDC7 Gene

This gene is involved in the initiation of DNA replication and inhibition of cell proliferation. It also plays a putative role in…