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CLEAVAGE
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I. (noun)
Sense 1
Meaning:
The act of cleaving or splitting
Classified under:
Nouns denoting acts or actions
Hypernyms ("cleavage" is a kind of...):
division (the act or process of dividing)
Derivation:
cleave (separate or cut with a tool, such as a sharp instrument)
Sense 2
Meaning:
The line formed by a groove between two parts (especially the separation between a woman's breasts)
Classified under:
Hypernyms ("cleavage" is a kind of...):
area; region (a part of an animal that has a special function or is supplied by a given artery or nerve)
Sense 3
Meaning:
(embryology) the repeated division of a fertilised ovum
Synonyms:
cleavage; segmentation
Classified under:
Nouns denoting natural processes
Hypernyms ("cleavage" is a kind of...):
cell division; cellular division (the process in reproduction and growth by which a cell divides to form daughter cells)
Domain category:
embryology (the branch of biology that studies the formation and early development of living organisms)
Holonyms ("cleavage" is a part of...):
gestation; maternity; pregnancy (the state of being pregnant; the period from conception to birth when a woman carries a developing fetus in her uterus)
Sense 4
Meaning:
The breaking of a chemical bond in a molecule resulting in smaller molecules
Classified under:
Nouns denoting natural processes
Hypernyms ("cleavage" is a kind of...):
chemical action; chemical change; chemical process ((chemistry) any process determined by the atomic and molecular composition and structure of the substances involved)
Sense 5
Meaning:
The state of being split or cleft
Example:
there was a cleavage between the liberal and conservative members
Classified under:
Nouns denoting stable states of affairs
Hypernyms ("cleavage" is a kind of...):
state (the way something is with respect to its main attributes)
Context examples:
Activated Notch cleavage by TACE and presenilin dependent gamma-secretase releases the intracellular domain to form a transcription complex with RBP-J kappa to activate enhancer of split genes.
(Notch Homolog 1, NCI Thesaurus)
This allele, which encodes poly(A) polymerase alpha protein, is involved in both the synthesis of the 3' poly(A) tail of mRNAs and endoribonucleolytic cleavage at some polyadenylation sites.
(PAPOLA wt Allele, NCI Thesaurus)
Phosphorylated inositols are released as second messengers by enzymatic cleavage of the phosphoinositides.
(Phosphoinositol Kinase Family Gene, NCI Thesaurus)
Enzymes that catalyze the cleavage of a phospholipid molecule by the addition of water, thereby causing hydrolysis.
(Phospholipase, NCI Thesaurus)
The most striking feature is the arrangement of the lesions such that the long axis is parallel to the lines of cleavage.
(Pityriasis Rosea, NLM, Medical Subject Headings)
This protein is released from the full length chromogranin-A protein by caspase cleavage and plays a role in the inhibition of the release of chromogranin-A, parathyroid hormone and somatostatin.
(Pancreastatin, NCI Thesaurus)
NPC targeting of NUP96 and NUP98 is cleavage dependent, which may regulate assembly of the NPC, comprised of nearly fifty nucleoporins involved in signal-mediated nuclear import and export of protein and RNA.
(Nucleoporin 98kD, NCI Thesaurus)
Binding of extracellular ligand to Notch also induces cleavage at the transmembrane region by a gamma-secretase activity that is dependent on presenilin-1.
(Notch Proteolysis and Signaling Pathway, NCI Thesaurus/BIOCARTA)
Interaction with ligand leads to two additional proteolytic cleavages that liberate the Notch intracellular domain (NICD) from the plasma membrane.
(Notch Signaling Pathway, NCI Thesaurus/KEGG)
The sulfo-SPDB linker prevents cleavage in the bloodstream and may improve this agent's efficacy in multidrug resistant tumor cells.
(Anti-FOLR1-Monoclonal Antibody-Maytansinoid Conjugate IMGN853, NCI Thesaurus)
