CYP1A1 wt Allele

Human CYP1A1 wild-type allele is located within 15q22-q24 and is approximately 6 kb in length. This allele, which encodes cytochrome P450 1A1 protein, plays a role in the metabolism of polyaromatic hydrocarbons (PAHs). Individuals with a high-inducibility phenotype, who exhibit elevated CYP1A1 gene expression in response to PAHs, may be at greater risk for cigarette smoke-induced bronchogenic carcinoma. (NCI Thesaurus)

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CYP1A1 Gene

This gene plays a role in the oxidation of procarcinogens. This process activates these compounds to carcinogens.

CYP19A1 wt Allele

Human CYP19A1 wild-type allele is located in the vicinity of 15q21.1 and is approximately 114 kb in length. This allele, which encodes…

CYP19A1 Gene

This gene is involved in development and estrogen metabolism.

CYP17A1 wt Allele

Human CYP17A1 wild-type allele is located in the vicinity of 10q24.3 and is approximately 7 kb in length. This allele, which encodes…

CYP17A1 Gene

This gene plays a role in the metabolism of estrogen and glucocorticoids. It is also involved in sexual maturation.

CYP17 Inhibitor CFG920

An orally available inhibitor of the steroid 17-alpha-hydroxylase/C17,20 lyase (CYP17A1 or CYP17), with potential antiandrogen and antineoplastic activities. Upon oral administration, CYP17…