Library / English Dictionary

CYTOCHROME

Pronunciation (US):

(GB):

 I. (noun) 

Sense 1

Meaning:

(biochemistry) a class of hemoprotein whose principal biological function is electron transfer (especially in cellular respiration)

Classified under:

Nouns denoting substances

Hypernyms ("cytochrome" is a kind of...):

haemoprotein; hemoprotein (a conjugated protein linked to a compound of iron and porphyrin)

Meronyms (substance of "cytochrome"):

haem; haemitin; hematin; heme; protoheme (a complex red organic pigment containing iron and other atoms to which oxygen binds)

Domain category:

biochemistry (the organic chemistry of compounds and processes occurring in organisms; the effort to understand biology within the context of chemistry)

Hyponyms (each of the following is a kind of "cytochrome"):

cytochrome c (the most abundant and stable cytochrome; involved in energy transfer)

Credits

 Context examples: 

Although the exact mechanism of action has yet to be fully elucidated, oxiconazole, like other azole antifungals, most likely inhibits the cytochrome P450-dependent demethylation of lanosterol.

(Oxiconazole, NCI Thesaurus)

Although the exact mechanism of action has yet to be fully elucidated, parconazole, like other azole antifungals, most likely inhibits the cytochrome P450 dependent 14 alpha demethylation of lanosterol.

(Parconazole, NCI Thesaurus)

The cytochrome P450 (CYP450) mono-oxygenase family of enzymes catalyzes the majority of the phase I reactions.

(Phase I Enzymes Inhibitor, NCI Thesaurus)

Silybin modulates P-glycoprotein (P-gp)-mediated cellular efflux; has oxygen radical-scavenging effects; inhibits the arachidonic acid pathway; and inhibits various cytochrome P450 enzymes.

(Phosphatidylcholine-Bound Silybin, NCI Thesaurus)

UL39 is replaced by the rat CYP2B1 gene, encoding a cytochrome P450 enzyme that activates oxazaphosphorines. rRp450 also expresses viral thymidine kinase, which activates the cancer prodrug ganciclovir.

(Oncolytic HSV-1 rRp450, NCI Thesaurus)

The first step in the pathway is catalyzed by a cytochrome P450 mixed function oxidase and requires both oxygen and NADPH.

(Omega-Oxidation of Fatty Acids Pathway, NCI Thesaurus/BIOCARTA)

NADPH—cytochrome P450 reductase (677 aa, ~77 kDa) is encoded by the human POR gene.

(NADPH--Cytochrome P450 Reductase, NCI Thesaurus)

This protein plays a role in the reduction of cytochrome c, doxorubicin, potassium ferricyanide and menadione.

(NADPH-Dependent Diflavin Oxidoreductase 1, NCI Thesaurus)

This agent is metabolized by the cytochrome P450 isoenzyme CYP2C9, and, to a lesser extent, by CYP3A4.

(Nateglinide, NCI Thesaurus)

A dihydrochloride salt form of azalanstat, a synthetic imidazole that inhibits hepatic cholesterol biosynthesis by inhibiting the cytochrome P450 enzyme lanosterol 14alpha-demethylase.

(Azalanstat Dihydrochloride, NCI Thesaurus)