Library / English Dictionary

HEME

Pronunciation (US):

(GB):

 I. (noun) 

Sense 1

Meaning:

A complex red organic pigment containing iron and other atoms to which oxygen binds

Synonyms:

haem; haemitin; hematin; heme; protoheme

Classified under:

Nouns denoting substances

Hypernyms ("heme" is a kind of...):

pigment (dry coloring material (especially a powder to be mixed with a liquid to produce paint, etc.))

Holonyms ("heme" is a substance of...):

haemoglobin; Hb; hemoglobin (a hemoprotein composed of globin and heme that gives red blood cells their characteristic color; function primarily to transport oxygen from the lungs to the body tissues)

myoglobin (a hemoprotein that receives oxygen from hemoglobin and stores it in the tissues until needed)

cytochrome ((biochemistry) a class of hemoprotein whose principal biological function is electron transfer (especially in cellular respiration))

Credits

 Context examples: 

The cytochrome P450 2C8*5 protein is predicted to be enzymatically inactive since it lacks 64% of the protein coding structure, a region which includes the heme binding site and 5 out of 6 substrate recognition sites.

(CYP2C8*5 Allele, NCI Thesaurus)

It could be involved in the transport of heme from the mitochondria to the cytosol.

(ATP-Binding Cassette, Sub-Family B, Member 6, NCI Thesaurus)

Although the mechanism of plasmodicidal action has not been fully elucidated, like other quinoline derivatives, amodiaquine likely is able to inhibit heme polymerase activity in the body.

(Amodiaquine, NCI Thesaurus)

In addition, CAPE inhibits PDGF-induced proliferation of vascular smooth muscle cells through the activation of p38 mitogen-activated protein kinase (MAPK) and hypoxia-inducible factor (HIF)-1alpha and subsequent induction of heme oxygenase-1 (HO-1).

(Caffeic Acid Phenethyl Ester, NCI Thesaurus)

This allele, which encodes 5-aminolevulinate synthase, nonspecific, mitochondrial protein, is involved in both heme biosynthesis and lipid metabolism.

(ALAS1 wt Allele, NCI Thesaurus)

This gene plays a role in both lipid metabolism and heme biosynthesis.

(ALAS1 Gene, NCI Thesaurus)

It is caused by a deficiency of the enzyme porphobilinogen deaminase, which is involved in heme biosynthesis.

(Acute Intermittent Porphyria, NCI Thesaurus)

A genetic hematologic disorder characterized by partial or complete absence of the alpha globin chains of the heme molecule.

(Alpha Thalassemia, NCI Thesaurus)

Upon hydrolysis of artesunate's active endoperoxide bridge moiety by liberated heme in parasite-infected red blood cells, reactive oxygen species and carbon-centered radicals form, which have been shown to damage and kill parasitic organisms.

(Artesunate, NCI Thesaurus)

This allele, which encodes mitochondrial ATP-binding cassette sub-family B member 6 protein, may play a role in the modulation of both synthesis and hemostasis of heme and porphyrins in mitochondria.

(ABCB6 wt Allele, NCI Thesaurus)