Health / Medical Topics

    DNA Ligation

    The joining together of two or more nucleic acid molecules by the action of ligase (NCI Thesaurus)




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    DNA ligase 4 (911 aa, ~104 kDa) is encoded by the human LIG4 gene. This protein plays a role in non-homologous end…
    DNA ligase 1 (919 aa, ~102 kDa) is encoded by the human LIG1 gene. This protein plays a role in DNA replication…
    A family of enzymes that catalyze the formation of phosphodiester bonds to repair broken strands of DNA.
    A collection of DNA molecules that have been cloned in vectors.
    DNA Intrastrand Crosslinking involves the formation of a covalent bond between two bases on the same DNA strand.
    DNA Interstrand Crosslinking involves the formation of a covalent bond between two bases on different DNA strand.

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