| Health / Medical Topics |
DNA Minor Groove Binding
DNA Minor Groove Binding involves temporary non-covalent interaction through intermolecular physical forces of attraction by a protein or low molecular weight ligand with double-stranded DNA in the smaller (minor) groove formed by the two antiparallel chains of the double helical structure, in either a sequence dependent or independent fashion. (NCI Thesaurus)
YOU MAY ALSO LIKE
An orderly array of DNA samples affixed to a support. Using robots thousands of samples can be arrayed on a single…
This term describes an experiment in which probes representing genes that one wants to study are affixed to a substrate (e.g., a…
A dinucleotide antimetabolite of a decitabine linked via phosphodiester bond to a guanosine, with potential antineoplastic activity. Following metabolic activation by phosphorylation…
Any substance that inhibits DNA methyltransferase, an enzyme required for DNA methylation. Inhibition of DNA methyltransferase results in hypomethylation of genomic DNA…
An enzyme (a protein that speeds up chemical reactions in the body) that attaches methyl groups to DNA. A methyl group is…
DNA Methylation Regulation involves cellular mechanisms that control covalent addition of methyl groups to specific cytosine residues of a DNA molecule, which…
