EGFR Inhibitor ABT-414

An epidermal growth factor receptor (EGFR) inhibitor, with potential antineoplastic activity. Upon intravenous infusion, ABT-414 inhibits the activity of EGFR, thereby preventing EGFR-mediated signaling. This may inhibit tumor growth in EGFR-overexpressing tumor cells. EGFR, a receptor tyrosine kinase overexpressed in certain tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization. (NCI Thesaurus)

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EGFR inhibitor

A substance that blocks the activity of a protein called epidermal growth factor receptor (EGFR). EGFR is found on the surface of…

EGFR Gene Product

A protein encoded by the EGFR gene.

EGFR Gene Mutation

A change in the nucleotide sequence of the EGFR gene.

EGFR Gene

This gene is involved in the epidermal growth factor signal transduction pathway.

EGFR CAR-CD3zeta-4-1BB-expressing Autologous T-Lymphocytes

Autologous human T-lymphocytes transduced with a retroviral vector encoding an anti-epidermal growth factor receptor (EGFR) chimeric T cell receptor (chimeric antigen receptor…

EGFR Antisense DNA

A synthetic sequence of DNA constructed in the antisense orientation to a sequence of DNA in epidermal growth factor receptor (EGFR), a…