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Endothelin Receptor Type A Antagonist
Definition 1
A group of agents that bind to the endothelin-1 receptor (primarily endothelin-A receptor, or ET-A), thereby inhibiting tumor cell proliferation and tumor associated angiogenesis. (NCI Thesaurus)
Definition 2
A substance that blocks the binding of the endothelin-1 protein to its receptor. Endothelin-1 is a small molecule that causes changes in blood vessels and helps regulate blood pressure. It can also stimulate the growth of some types of cells. (NCI Dictionary)
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