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Eosinophilic Granuloma
Definition 1
A clinical variant of Langerhans cell histiocytosis characterised by unifocal involvement of a bone (most often), skin, or lung. Patients are usually older children or adults usually presenting with a lytic bone lesion. The etiology is unknown. Morphologically, eosinophilic granuloma is characterised by the presence of Langerhans cells in a characteristic milieu which includes histiocytes, eosinophiles neutrophiles, and small, mature lymphocytes. (NCI Thesaurus)
Definition 2
The most benign clinical form of Langerhans-cell histiocytosis (HISTIOCYTOSIS, LANGERHANS-CELL), which involves localized nodular lesions of the gastric mucosa, small intestine, bones, lungs, or skin, with infiltration by eosinophils. The proliferating cell that appears to be responsible for the clinical manifestations is the Langerhans cell. (NLM, Medical Subject Headings)
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