Gataparsen Sodium

A second-generation antisense oligonucleotide against survivin mRNA with potential antitumor activity. Oligonucleotide LY2181308 hybridizes to survivin mRNA, thereby blocking translation of survivin protein, a member of the inhibitor of apoptosis (IAP) family. Survivin, expressed during embryonal development, is upregulated in a variety of human cancers while absent in most normal adult cells; its expression in tumors is associated with a more aggressive phenotype, shorter survival times, and a decreased response to chemotherapy. Silencing expression of survivin potentially leads to restoration of the apoptotic process in cancer cells, thereby facilitating chemotherapeutic treatments. (NCI Thesaurus)

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GATA6 wt Allele

Human GATA6 wild-type allele is located within 18q11-q12 and is approximately 33 kb in length. This allele, which encodes transcription factor GATA-6…

GATA6 Gene

This gene plays a role in regulation of cellular differentiation and organogenesis during development.

GATA5 wt Allele

Human GATA5 is located within 20q13.33 and is approximately 12 kb in length. This gene, which encodes transcription factor GATA-5 protein, plays…

GATA5 Gene

This gene is involved in transcriptional regulation.

GATA4 wt Allele

Human GATA4 wild-type allele is located within 8p23.1-p22 and is approximately 56 kb in length. This allele, which encodes transcription factor GATA-4…

GATA4 Gene

This gene is involved in transcriptional regulation.