HDAC6 Inhibitor ACY-1215

An orally bioavailable, specific inhibitor of histone deacetylase 6 (HDAC6) with potential antineoplastic activity. ACY-1215 selectively targets and binds to HDAC6, thereby disrupting the Hsp90 protein chaperone system through hyperacetylation of Hsp90 and preventing the subsequent aggresomal protein degradation. This leads to an accumulation of unfolded and misfolded ubiquitinated proteins and may eventually induce cancer cell apoptosis, and inhibition of cancer cell growth. HDAC6, a class II HDAC deacetylase located in the cytoplasm, appears to play a key role in the formation and activation of the aggresomes needed for degradation of misfolded proteins. Compared to non-selective HDAC inhibitor, ACY-1215 is able to reduce the toxic effects on normal, healthy cells. (NCI Thesaurus)

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HDAC6 Gene

This gene is involved in chromatin remodeling, repression of gene expression and cellular management of misfolded protein-induced stress.

HDAC5 wt Allele

Human HDAC5 wild-type allele is located within 17q21 and is approximately 47 kb in length. This allele, which encodes histone deacetylase 5…

HDAC5 Gene

This gene plays a role in chromatin remodeling, repression of gene expression and control of cellular differentiation.

HDAC4 wt Allele

Human HDAC4 wild-type allele is located in the vicinity of 2q37.2 and is approximately 352 kb in length. This allele, which encodes…

HDAC4 Gene

This gene is involved in chromatin remodeling, repression of gene expression and myoblast differentiation.

HDAC3 wt Allele

Human HDAC3 wild-type allele is located within 5q31 and is approximately 16 kb in length. This allele, which encodes histone deacetylase 3…