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Histiocytic Sarcoma
Definition 1
An aggressive malignant neoplasm with a poor response to therapy, usually presenting as stage III/IV disease. It is characterized by the presence of neoplastic cells with morphologic and immunophenotypic characteristics similar to those seen in mature histiocytes. (NCI Thesaurus)
Definition 2
A malignant neoplasm composed of cells resembling histiocytes. (NCI Thesaurus/CDISC)
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