HMG-CoA reductase inhibitor

Pronunciation

Definition 1

A substance that blocks an enzyme needed by the body to make cholesterol and lowers the amount of cholesterol in the blood. HMG-CoA reductase inhibitor drugs are called statins. Also called hydroxymethylglutaryl-coenzyme A reductase inhibitor. (NCI Dictionary)

Definition 2

Any substance that inhibits HMG-CoA reductase, a key enzyme in cholesterol synthesis. Inhibition of HMG-CoA reductase acts to lower plasma cholesterol and lipoprotein levels. (NCI Thesaurus)

Definition 3

Any of a group of drugs that lower the amount of cholesterol and certain fats in the blood. Statins inhibit a key enzyme that helps make cholesterol. Statin drugs are being studied in the prevention and treatment of cancer. (NCI Dictionary)

Definition 4

Compounds that inhibit HMG-CoA reductases. They have been shown to directly lower cholesterol synthesis. (NLM, Medical Subject Headings)

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