I Kappa B-Alpha Protein

Definition 1

Encoded by glucocorticoid-inducible human NFKBIA Gene (NFKBI Family), 317-aa 36-kDa cytoplasmic I-Kappa-B-Alpha contains 5 ANK repeats that interact with p65 RELA C-terminal REL homology regions. By complexing with and trapping NFKB in the cytoplasm, unphosphorylated NFKBIA inhibits NFKB target gene transcription in cell adhesion, immune and proinflammatory responses, apoptosis, differentiation, and growth. NFKBIA tyrosine phosphorylation leads to dissociation from NFKB, disabling inhibition of NFKB DNA-binding. Stimulus-dependent IKBKA/IKBKB serine phosphorylation of NFKBIA results in polyubiquitination and for rapid degradation via the ubiquitin system. (NCI Thesaurus)

Definition 2

One of a number of ankyrin-rich proteins known as IkappaB that interact with and regulate members of the Rel/NF-kappaB family of transcription factors. IkappaB-alpha is the inhibitory subunit of NF-kappaB. (NCI Thesaurus)

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