IGF-1 Signaling Pathway

Insulin like growth factor 1 (IGF-1) and its receptor (IGF-1R) provide a potent proliferative signaling system that stimulates growth in many different cell types and blocks apoptosis. In vivo IGF-1 acts as an intermediate of many growth hormone responses, and may stimulate the growth of some types of cancer. IGF-1 also provides a mitogenic signal to act as a growth factor for many tissue culture cells. One component of IGF-1 mitogenic signaling is association of the receptor tyrosine kinase with Shc, Grb2, and Sos-1 to activate ras and the Map kinase cascade (raf, Mek, Erk). An endpoint of the Map kinase pathway is modification of transcription factor activity, such as activation of ELK transcription factors. Serum response factor (SRF) and AP-1 contribute to mitogenic signaling by many factors. Phosphorylation of IRS-1 and PI3 kinase activation are also involved in IGF-1 signaling, similar to insulin signaling. (NCI Thesaurus/BIOCARTA)

YOU MAY ALSO LIKE

IGF Ligand Neutralizing Antibody BI 836845

A humanized IgG1 insulin-like growth factor (IGF) monoclonal antibody targeting the IGF ligands 1 (IGF-1) and 2 (IGF-2), with potential antineoplastic…

IGF

A protein made by the body that stimulates the growth of many types of cells. IGF is similar to insulin (a hormone…

IgE

An immunoglobulin isotype (subclass). This isotype has the unique ability to bind with high affinity to IgE receptors (FceRI) on mast…

IgD

An immunoglobulin isotype (subclass). This isotype is expressed on naive B cells along with IgM. Little is known about its…

IGBP1 wt Allele

Human IGBP1 wild-type allele is located within Xq13.1-q13.3 and is approximately 33 kb in length. This allele, which encodes immunoglobulin-binding protein 1,…

IGBP1 Gene

This gene is involved in multiple signal transduction pathways.