IgG Fc Receptor IIB

Expressed as 3 alternative isoforms in monocytes, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B cells, platelets, and placental endothelial by human FCGR2B Gene, IgG Fc Receptor IIB is a type I cell surface protein with 2 IgC2 domains and the most broadly distributed low affinity receptor for aggregated IgG Fc region. FCGR2B binding to IgG initiates essential effector and regulatory cellular responses against foreign pathogens and soluble antigens that induce phagocytosis of antigen-antibody complexes, removing them from circulation, and modulate B-cell antibody production. FCGR2B contains a cytoplasmic ITIM motif involved in down modulation of previous cell activation by BCR, TCR or another Fc receptor; phosphorylated ITIM binds to PTPN6/SHP-1 SH2 domain. Chromosome translocation t(1;22)(q22;q11) leads to FCGR2B hyperexpression in a follicular lymphoma. (NCI Thesaurus)

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