Immunoconjugate RO5479599

An immunoconjugate containing a glycoengineered, humanized monoclonal antibody directed against the human epidermal growth factor receptor HER3 (ErbB3), with potential antineoplastic activity. Upon administration, RO5479599 binds to the extracellular domain of HER3 and inhibits HER3 dimerization; thereby, preventing EGFR-dependent signaling. In addition, RO5479599 stimulates the immune system to exert antibody-dependent cellular cytotoxicity (ADCC). This may decrease proliferation of HER3-overexpressing tumor cells. HER3, a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases, is frequently overexpressed in tumors; it has no active kinase domain but is activated through heterodimerization with other members of the EGFR receptor family, such as HER2. (NCI Thesaurus)

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An agent that consists of an immune substance, such as a monoclonal antibody, antigen or an immunoglobulin, and covalently bound to other…

Immunocompromised

Having a weakened immune system caused by certain diseases or treatments.

Immunocompetent

Having the ability to produce a normal immune response.

Immunocompetence

The ability to produce a normal immune response.

Immunochemistry

The field of chemistry concerned with chemical processes in immunology (such as chemical studies of antigens and antibodies).

Immunochemiluminometric Assay

A type of immunoassay in which the antigen-antibody complex is quantified using light emission, which is generated from a chemical reaction. …