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Leuprolide acetate
Pronunciation
Definition 1
A drug used to treat advanced prostate cancer. Under the brand name Lupron, it is also used to treat early puberty in children and certain gynecologic conditions. Leuprolide acetate is also being studied in the treatment of other types of cancer. It blocks the testicles from making testosterone (a male hormone) and the ovaries from making estrogen and progesterone (female hormones). It may stop the growth of prostate cancer cells that need testosterone to grow. Leuprolide acetate is a type of gonadotropin-releasing hormone (GnRH) agonist. Also called Eligard, Lupron, and Viadur. (NCI Dictionary)
Definition 2
The acetate salt of a synthetic nonapeptide analogue of gonadotropin-releasing hormone. Leuprolide binds to and activates gonadotropin-releasing hormone (GnRH) receptors. Continuous, prolonged administration of leuprolide in males results in pituitary GnRH receptor desensitization and inhibition of pituitary secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to a significant decline in testosterone production; in females, prolonged administration results in a decrease in estradiol production. This agent reduces testosterone production to castration levels and may inhibit androgen receptor-positive tumor progression. (NCI Thesaurus)
Definition 3
A drug used to treat symptoms of advanced prostate cancer. It is also being studied in the treatment of other conditions and types of cancer. The active ingredient leuprolide blocks the body from making testosterone (a male hormone) and estradiol (a female hormone). It may stop the growth of prostate cancer cells that need testosterone to grow. Some brands of leuprolide are also used to treat early puberty in children and certain gynecologic conditions. Leuprolide acetate is a type of gonadotropin-releasing hormone analog. (NCI Dictionary)
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