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LMB-1 immunotoxin
Pronunciation
Definition 1
A toxic substance linked to an antibody that attaches to tumor cells and kills them. (NCI Dictionary)
Definition 2
A chimeric protein consisting of the Fv portion of a monoclonal antibody attached to a fragment of Pseudomonas exotoxin A without its cell-binding region. LMB-1 immunotoxin targets B3, a Lewis Y-related carbohydrate epitope found on some solid tumors. The antibody attaches to the tumor cell and the exotoxin stops protein synthesis by inactivating elongation factor 2. (NCI Thesaurus)
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