MLH1 Protein

MLH1 protein is a DNA-binding, DNA-mismatch repair protein, of the MutL/HexB family, that dimerizes with PMS2 or MLH3. MLH1 is part of the multi-subunit BASC repair complex containing ATM, BLM, MSH2, MSH6, BRCA1, the RAD50/MRE11/NBS1 complex, and the RFC1/RFC2/RFC4 complex. MLH1 is homologous to MutL, which hydrolyzes ATP. (from OMIM 120436 and NCI) (NCI Thesaurus)

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This gene plays a role in DNA mismatch repair.

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This gene plays a role in the development and maturation of melanosomes.

Ml

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