Health / Medical Topics

    Observed Area Under the Curve Percent Extrapolation

    Definition 1

    The percentage of the area under the curve (AUC) extrapolated to infinity observed from Tlast to infinity. (NCI Thesaurus)

    Definition 2

    Applies only for intravascular bolus dosing. The area under the curve (AUC) from the first measured concentration value back extrapolated to the concentration value at time zero as a percentage of the area under the curve extrapolated to infinity using the predicted value of the last non-zero concentration. (NCI Thesaurus/CDISC)




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