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Observed Steady State Volume of Distribution
Definition 1
An estimate of the volume of distribution at steady state, which is the mean residence time (MRT) extrapolated to infinity times steady state clearance (MRTINF*Clss), based on the last observed concentration. (NCI Thesaurus)
Definition 2
The volume of distribution at steady state based on the observed CLST for a substance administered by intravascular dosing. (NCI Thesaurus/CDISC)
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The observed mean residence time (MRT) extrapolated to infinity.
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The area under the urinary excretion rate curve (AURC) extrapolated to infinity, based on the last observed excretion rate.
The percent of the observed area under the first moment curve (AUMC) that is extrapolated to infinity.
The area under the first moment curve (AUMC) extrapolated to infinity, based on the last observed concentration.
The percentage of the area under the curve (AUC) extrapolated to infinity observed from Tlast to infinity.
