ONYX-015

Definition 1

A modified cold virus that selectively grows in and destroys certain types of cancer cells and leaves normal cells undamaged. (NCI Dictionary)

Definition 2

An E1B-55kDa-deleted adenovirus that is able to selectively replicate in and lyse TP53-deficient human tumor cells. After tumor cell lysis, released viruses infect neighboring tumor cells, tripping a chain of ONYX-015-mediated tumor cell cytotoxicity. (NCI Thesaurus)

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