Paclitaxel-loaded polymeric micelle

Pronunciation

Definition 1

A form of the anticancer drug paclitaxel used to treat breast cancer, ovarian cancer, and AIDS-related Kaposi sarcoma. It is also used with another drug to treat non-small cell lung cancer. Paclitaxel is mixed with very tiny particles of a substance that makes it easier to dissolve in water. This allows higher doses of paclitaxel to be given. It is a type of antimitotic agent. (NCI Dictionary)

Definition 2

A biodegradable poly(ethylene glycol)-poly(D,L-lactide) copolymer micelle nanoparticle-entrapped formulation of paclitaxel with antineoplastic activity. Paclitaxel promotes microtubule assembly and prevents depolymerization, thus interfering with normal mitosis. The copolymer residue increases the water-solubility of paclitaxel and allows delivery of higher doses than those achievable with paclitaxel alone. (NCI Thesaurus)

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