Library / English Dictionary

PEPTIDASE

Pronunciation (US):

(GB):

 I. (noun) 

Sense 1

Meaning:

Any enzyme that catalyzes the splitting of proteins into smaller peptide fractions and amino acids by a process known as proteolysis

Synonyms:

peptidase; protease; proteinase; proteolytic enzyme

Classified under:

Nouns denoting substances

Hypernyms ("peptidase" is a kind of...):

enzyme (any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions)

Hyponyms (each of the following is a kind of "peptidase"):

caspase (any of a group of proteases that mediate apoptosis)

ACE; angiotensin-converting enzyme; angiotensin converting enzyme (proteolytic enzyme that converts angiotensin I into angiotensin II)

plasminogen activator; urokinase (protease produced in the kidney that converts plasminogen to plasmin and so initiates fibrinolysis)

renin (a proteolytic enzyme secreted by the kidneys; catalyzes the formation of angiotensin and thus affects blood pressure)

Credits

 Context examples: 

This allele encodes putative macrophage-stimulating protein MSTP9, a non-functional member of the peptidase S1 family.

(MST1L wt Allele, NCI Thesaurus)

ACE is a di-peptidase, cleaving off 2 peptides from the c-terminal end of angiotensin.

(Angiotensin-converting Enzyme 2 Pathway, NCI Thesaurus/BIOCARTA)

A potent, long-acting, selective, orally bioavailable, pyrrolidinone-based inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity.

(Carmegliptin, NCI Thesaurus)

A potent, selective, orally bioavailable, fluoropyrrolidine-based inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity.

(Denagliptin, NCI Thesaurus)

This gene encodes a non-functional member of the peptidase S1 family.

(MST1L Gene, NCI Thesaurus)

Upon administration, the dipeptide bond in the melphalan-flufenamide compound is hydrolyzed by peptidases, which are overexpressed by certain cancer cells.

(Melphalan-Flufenamide Prodrug, NCI Thesaurus)

A potent, selective and orally bioavailable, cyanopyrrolidine-based inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity.

(Melogliptin, NCI Thesaurus)

LLME undergoes a condensation process catalyzed by dipeptidyl peptidase I (DPPI) in lysosomes.

(L-Leucyl-L-Leucine Methyl Ester, NCI Thesaurus)

A potent, water soluble, selective and orally bioavailable, boronic acid-based inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity.

(Dutogliptin, NCI Thesaurus)

The benzoate salt form of alogliptin, a selective, orally bioavailable, pyrimidinedione-based inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity.

(Alogliptin Benzoate, NCI Thesaurus)