Library / English Dictionary

PROTEINASE

Pronunciation (US):

(GB):

 I. (noun) 

Sense 1

Meaning:

Any enzyme that catalyzes the splitting of proteins into smaller peptide fractions and amino acids by a process known as proteolysis

Synonyms:

peptidase; protease; proteinase; proteolytic enzyme

Classified under:

Nouns denoting substances

Hypernyms ("proteinase" is a kind of...):

enzyme (any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions)

Hyponyms (each of the following is a kind of "proteinase"):

caspase (any of a group of proteases that mediate apoptosis)

ACE; angiotensin-converting enzyme; angiotensin converting enzyme (proteolytic enzyme that converts angiotensin I into angiotensin II)

plasminogen activator; urokinase (protease produced in the kidney that converts plasminogen to plasmin and so initiates fibrinolysis)

renin (a proteolytic enzyme secreted by the kidneys; catalyzes the formation of angiotensin and thus affects blood pressure)

Credits

 Context examples: 

This protein plays a role in the inhibition of neutrophil and pancreatic elastase proteinase activity.

(Elafin, NCI Thesaurus)

Several amoebic proteins such as lectins, cysteine proteinases, and amoebapores are associated with the invasion process.

(Amoebiasis Pathway, NCI Thesaurus/KEGG)

Lysosomal proteinases or endopeptidases that function optimally at an acidic pH to catalyze the hydrolysis of peptidic bonds.

(Cathepsin, NCI Thesaurus)

Human Cysteine Proteinase Inhibitor Genes encode Cysteine Proteinase Inhibitors, endogenous proteins that hinder the function of cysteine proteinases.

(Cysteine Proteinase Inhibitor Gene, NCI Thesaurus)

Caspases are a family of intracellular cysteine proteinases involved in inflammation and apoptosis.

(Caspase, NCI Thesaurus)

Cystatins are intracellular or extracellular, tight, reversible, competitive inhibitors of lysosomal cysteine proteinases, such as Cathepsins B, L, H, and S, that appear to provide a protective function.

(Cystatin Superfamily Gene, NCI Thesaurus)

As a broad-spectrum serine protease inhibitor, aprotinin bovine competitively and reversibly inhibits the activity of a number of different esterases and proteases, including trypsin, chymotrypsin, kallikrein, plasmin, tissue plasminogen activator, and tissue and leukocytic proteinases, resulting in attenuation of the systemic inflammatory response (SIR), fibrinolysis, and thrombin generation.

(Aprotinin, NCI Thesaurus)

Upon administration, AAT reduces the production of proinflammatory cytokines, such as tumor necrosis factor-alpha, interleukin (IL)-1 beta, IL-32, IL-6, and proteinase 3, and induces the production of anti-inflammatory cytokines, such as IL-10 and the IL-1 receptor antagonist IL-1RN.

(Alpha-1-Proteinase Inhibitor Human, NCI Thesaurus)