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PLASMID DNA
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I. (noun)
Sense 1
Meaning:
A small cellular inclusion consisting of a ring of DNA that is not in a chromosome but is capable of autonomous replication
Synonyms:
plasmid; plasmid DNA
Classified under:
Nouns denoting natural objects (not man-made)
Hypernyms ("plasmid DNA" is a kind of...):
cellular inclusion; inclusion; inclusion body (any small intracellular body found within another (characteristic of certain diseases))
Context examples:
A plasmid DNA encoding human manganese superoxide dismutase (MnSOD) and liposomally encapsulated with potential chemoprotective activity.
(Liposomal MnSOD Plasmid, NCI Thesaurus)
A non-viral expression system using multifunctional plasmid DNA to deliver disease-specific to immune cells and encode peptides/proteins to modulate various diseases.
(Biotope CD, NCI Thesaurus)
A novel non-viral vector consisting of a plasmid DNA encoding the human gene for interleukin 12 (IL-12) and a biocompatible, biodegradable delivery polymer with potential antineoplastic activity.
(EGEN-001, NCI Thesaurus)
Upon administration, CYL-02 plasmid DNA expresses DCK::UMK fusion protein that converts gemcitabine into its toxic phosphorylated metabolite.
(CYL-02 Plasmid DNA, NCI Thesaurus)
A cancer vaccine composed of naked plasmid DNA of the gene for the tumor-associated antigen alpha-fetoprotein (AFP), a macromolecule that acts as a specific immunologic target for hepatocellular carcinoma.
(AFP Gene Hepatocellular Carcinoma Vaccine, NCI Thesaurus)
A plasmid DNA encoding the A chain of the diphtheria toxin (DT-A) driven by the transcriptional regulatory sequences of human H19, with potential antineoplastic activity.
(DTA-H19 Plasmid, NCI Thesaurus)
An immunotherapeutic agent consisting of a plasmid DNA encoding human Interleukin-2 (IL-2) complexed with a cationic lipid, 1,2-dimyristyloxypropyl-3-dimethyl-hydroxyethyl ammonium bromide/dioleyl-phosphatidyl-ethanolamine (DMRIE/DOPE), in a 5:1 ratio.
(IL-2 Plasmid DNA/Lipid Complex, NCI Thesaurus)
A plasmid DNA encoding for the A fragment of Diphtheria Toxin (DTA) under the control of the H19 gene promoter (BC-819 or DTA-H19) and mixed with the transfectant polyethylenimine (PEI), with potential antineoplastic activity.
(BC-819 Plasmid/Polyethylenimine Complex, NCI Thesaurus)
A plasmid DNA encoding an immunogenic peptide derived from the cancer-testis antigen NY-ESO-1 with potential immunostimulating and antitumor activities.
(NY-ESO-1 Plasmid DNA Cancer Vaccine, NCI Thesaurus)
Upon administration, murine TYRP2 plasmid DNA vaccine may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells expressing TYRP2; this vaccine may also induce an immune response against tyrosinase-related protein-1 (TYRP1).
(Murine TYRP2 Plasmid DNA Vaccine, NCI Thesaurus)
