Platelet Derived Growth Factor Beta Chain

Definition 1

Expressed as 2 alternative isoforms in platelets by human PDGFB Gene (PDGF/VEGF Family), 241-aa 27-kDa (precursor) Platelet-Derived Growth Factor-Beta Chain is a potent mitogenic factor for mesenchymal cells characterized by a motif of eight cysteines and released by platelets upon wounding to stimulate adjacent cell growth. PDGFB can exist as either antiparallel disulfide-linked homodimers or heterodimers with Platelet-Derived Growth Factor Alpha. A-A, B-B, and A-B, dimers can bind to PDGF receptor and elicit a variety of cellular responses. A and B homodimers are implicated in transformation processes. PDGFB mutations are associated with meningioma. Reciprocal t(17;22)(q22;q13) translocations with COL1A1 result in unregulated growth factor expression and are associated with DFSP. (NCI Thesaurus)

Definition 2

PDGF has dissimilar A and B subunits. Encoded by the PDGFB gene, Platelet Derived Growth Factor Beta Chain alone is sufficient for the mitogenic effects of PDGF. PDGF promotes cell proliferation and inhibits apoptosis. PDGF activates a RAS/PIK3/AKT1/IKK/NFKB1 pathway that induces putative anti-apoptotic genes. (from OMIM 190040 and NCI) (NCI Thesaurus)

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