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RARA/ZBTB16 Fusion Gene
A fusion gene that results from a chromosomal translocation t(11;17)(q23;q21) which fuses the exon 3 of the RARA gene to the 3' portion of the ZBTB16 gene. This rearrangement is associated with acute promyelocytic leukemia. (NCI Thesaurus)
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A fusion gene that results from a chromosomal translocation t(15;17)(q22;q21) which fuses the first 2 exons of the RARA gene with the…
Human RARA wild-type allele is located within 17q21 and is approximately 48 kb in length. This allele, which encodes retinoic acid receptor…
This gene plays a role in transcription and retinoic acid receptor signal transduction.
Once retinoids are bound by the RAR/RXR heterodimer they became transcriptional activated. As a consequence they are degraded by the proteasome. Phosphorylation…
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Acting or occurring in a brief period of time.
