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REVERSE TRANSCRIPTASE
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
A polymerase that catalyzes the formation of DNA using RNA as a template; found especially in retroviruses
Classified under:
Hypernyms ("reverse transcriptase" is a kind of...):
polymerase (an enzyme that catalyzes the formation of new DNA and RNA from an existing strand of DNA or RNA)
Context examples:
Michellamine B inhibits HIV reverse transcriptase (RT) activity and HIV-induced cellular fusion and syncytium formation, thereby inhibiting viral propagation.
(Michellamine B, NCI Thesaurus)
Capravirine shows antiviral activity against wild-type HIV as well as HIV strains with mutations in reverse transcriptase.
(Capravirine, NCI Thesaurus)
A nucleoside reverse transcriptase inhibitor prodrug analog of guanosine.
(Amdoxovir, NCI Thesaurus)
A nucleoside reverse transcriptase inhibitor analog of thymidine.
(Alovudine, NCI Thesaurus)
Following amplification of reverse transcriptase polymerase chain reaction assay, the quantified amount of the target gene divided by the quantified amount of housekeeping gene.
(Normalized Quotient, NCI Thesaurus)
A nucleoside reverse transcriptase inhibitor analog of adenosine with activity against hepatitis B virus (HBV), herpes virus, and human immunodeficiency virus (HIV).
(Adefovir, NCI Thesaurus)
The incorporation of the activated triphosphate metabolite of entecavir inhibits the reverse transcriptase (RT) viral RNA-dependent HBV DNA polymerase and, so, the replication of viral DNA and transcription.
(Entecavir, NCI Thesaurus)
Mechanisms to suppress growth include inhibition of cell wall synthesis; increased cell wall permeability; protein synthesis inhibition; and inhibition of reverse transcriptase and protease.
(Antimicrobial Effect, NCI Thesaurus)
A mesylate salt form of atevirdine, a non-nucleoside reverse transcriptase inhibitor.
(Atevirdine Mesylate, NCI Thesaurus)
A succinate salt form of abacavir, a nucleoside reverse transcriptase inhibitor analog of guanosine.
(Abacavir Succinate, NCI Thesaurus)
